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BDBM224930 US9321756, 189

SMILES: Nc1nnc(s1)-c1ccc2[nH]cc(-c3cnc(cn3)N3CCCC3)c2c1

InChI Key: InChIKey=PZCSBWJSPSARQH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224930   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224930
PNG
(US9321756, 189)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cnc(cn3)N3CCCC3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-24-23-17(26-18)11-3-4-14-12(7-11)13(8-20-14)15-9-22-16(10-21-15)25-5-1-2-6-25/h3-4,7-10,20H,1-2,5-6H2,(H2,19,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 73.2n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM224930
PNG
(US9321756, 189)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cnc(cn3)N3CCCC3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-24-23-17(26-18)11-3-4-14-12(7-11)13(8-20-14)15-9-22-16(10-21-15)25-5-1-2-6-25/h3-4,7-10,20H,1-2,5-6H2,(H2,19,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 690n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224930
PNG
(US9321756, 189)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cnc(cn3)N3CCCC3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-24-23-17(26-18)11-3-4-14-12(7-11)13(8-20-14)15-9-22-16(10-21-15)25-5-1-2-6-25/h3-4,7-10,20H,1-2,5-6H2,(H2,19,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 564n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair