BDBM225230 EED226::US11013745, Compound EED226
SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12
InChI Key InChIKey=DYIRSNMPIZZNBK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 90 hits for monomerid = 225230
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 23.4nMpH: 8.0Assay Description:To assess the compounds potency in the H3K27me0 peptide (21–44)-based PRC2 enzymatic assay, compounds were serially diluted three-fold in DMSO t...More data for this Ligand-Target Pair
3D Structure (crystal)TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 53.5nMpH: 8.0Assay Description:To assess the compounds potency in the H3K27me0 peptide (21–44)-based PRC2 enzymatic assay, compounds were serially diluted three-fold in DMSO t...More data for this Ligand-Target Pair
Affinity DataKd: 82nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12 [559-739](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataKd: 114nMpH: 8.0 T: 2°CAssay Description:ITC experiments were performed by Auto ITC200 (Microcal) at 25 °C. ITC sample cell was filled with 10 μM PRC2 in titration buffer (25 mM HEPES p...More data for this Ligand-Target Pair
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 20nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 50nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase 2A/Retinoblastoma-binding protein 5/Set1/Ash2 histone methyltransferase complex subunit ASH2/WD repeat-containing protein 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetN-lysine methyltransferase SETD6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetN-lysine methyltransferase SMYD2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SUV39H2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SETDB1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SETD2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [64-515](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2 [406-821](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4 [388-802](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [563-993,D835Y](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 1 [184-712](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2 [807-1356](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 8 [30-404](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha [551-1089,V561D](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2 [6-553](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17B(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK [2-635](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >3.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair