BDBM22566 5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole::CHEMBL129198::JNJ 7777120

SMILES: CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key: InChIKey=HUQJRYMLJBBEDO-UHFFFAOYSA-N

Data: 80 KI  10 IC50  1 Kd  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 95 hits for monomerid = 22566   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	741	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Mouse)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	794	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	199	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	221	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H1 receptor (Guinea pig)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Mouse)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.60	-11.7	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.70	-11.7	n/a	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		2.70	-11.7	n/a	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Mouse)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		3.89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.10	-11.4	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Mouse)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.60	-11.4	n/a	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.70	-11.4	n/a	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Rat)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H4 receptor (Human)	BDBM22566 (CHEMBL129198 | 5-chloro-2-[(4-methylpiperazin-1-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair