BDBM225845 Polyhydroxy benzophenone, 7::hsp90_136

SMILES c1cc(ccc1C(=O)c2ccc(c(c2O)O)O)O

InChI Key InChIKey=ZRDYULMDEGRWRC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 225845   

TargetHeat shock protein HSP 90-beta(Human)
D3R/Abbott

LigandPNGBDBM225845(hsp90_136 | Polyhydroxy benzophenone, 7 | US123770...)
Affinity DataIC50: 903nMAssay Description:FRET Assay 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM225845(hsp90_136 | Polyhydroxy benzophenone, 7 | US123770...)
Affinity DataKi:  7.10E+3nMAssay Description:Nitrocefin (Cayman, CAS 41906-86-9) was used as the chromogenic substrate for all biochemical assays. The enzymatic activity of purified VIM-2 and ND...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM225845(hsp90_136 | Polyhydroxy benzophenone, 7 | US123770...)
Affinity DataKi:  8.80E+3nMAssay Description:VIM-2 was diluted to 6 μM with 50 mM HEPES, pH 7.5, containing 150 mM NaCl. The diluted protein solution was used to make several 5 mL aliquots. L-Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM225845(hsp90_136 | Polyhydroxy benzophenone, 7 | US123770...)
Affinity DataIC50: 6.80E+4nMAssay Description:Nitrocefin (Cayman, CAS 41906-86-9) was used as the chromogenic substrate for all biochemical assays. The enzymatic activity of purified VIM-2 and ND...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM225845(hsp90_136 | Polyhydroxy benzophenone, 7 | US123770...)
Affinity DataIC50: 8.10E+4nMAssay Description:VIM-2 was diluted to 6 μM with 50 mM HEPES, pH 7.5, containing 150 mM NaCl. The diluted protein solution was used to make several 5 mL aliquots. L-Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Sun Yat-Sen University

LigandPNGBDBM225845(hsp90_136 | Polyhydroxy benzophenone, 7 | US123770...)
Affinity DataIC50: 1.00E+5nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed