BDBM22590 (2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid::5,10-dideazatetrahydrofolic acid::DDATHF::DDF::Lometrexol

SMILES: Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1

InChI Key: InChIKey=ZUQBAQVRAURMCL-UHFFFAOYSA-N

Data: 8 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 22590   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Trifunctional purine biosynthetic protein adenosine-3 (Mouse)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
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Trifunctional purine biosynthetic protein adenosine-3 (Human)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
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Trifunctional purine biosynthetic protein adenosine-3 (Human)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Trifunctional purine biosynthetic protein adenosine-3 (Human)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		60	-9.88	n/a	n/a	n/a	n/a	n/a	7.5	26
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					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Human)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		60	-9.88	n/a	n/a	n/a	n/a	n/a	7.5	26
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					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Mouse)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphoribosylglycinamide formyltransferase (Escherichia coli (strain K12))	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		100	-9.57	n/a	n/a	n/a	n/a	n/a	7.5	26
TBA									Citation and Details
					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Mouse)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Human)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Bifunctional purine biosynthesis protein ATIC (Human)	BDBM22590 (5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+5	>-5.47	n/a	n/a	n/a	n/a	n/a	7.4	26
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					More data for this Ligand-Target Pair