BindingDB logo
myBDB logout

BDBM226551 US9328096, 244

SMILES: Cn1ccnc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1

InChI Key: InChIKey=LENKNYSYGWVEEN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 226551   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM226551
PNG
(US9328096, 244)
Show SMILES Cn1ccnc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1
Show InChI InChI=1S/C27H21ClFN7O2/c1-35-13-12-30-24(35)16-32-27(38)22-15-23(36(34-22)18-6-3-2-4-7-18)33-26(37)19-14-17(9-10-20(19)28)25-21(29)8-5-11-31-25/h2-15H,16H2,1H3,(H,32,38)(H,33,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 374n/an/an/an/an/a37



Pfizer Inc

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair