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BDBM227132 US9328096, 820

SMILES: CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1

InChI Key: InChIKey=QFDQPCSBPJEEOC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227132   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM227132
PNG
(US9328096, 820)
Show SMILES CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H23ClFN5O3/c1-26(2,36)15-30-25(35)21-14-22(33(32-21)17-7-4-3-5-8-17)31-24(34)18-13-16(10-11-19(18)27)23-20(28)9-6-12-29-23/h3-14,36H,15H2,1-2H3,(H,30,35)(H,31,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 101n/an/an/an/an/a37



Pfizer Inc

US Patent


Assay Description
TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...


US Patent US9328096 (2016)


BindingDB Entry DOI: 10.7270/Q2FN152J
More data for this
Ligand-Target Pair