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BDBM227331 US9328106, 282

SMILES: Cn1ncc(NC(=O)c2nc(sc2N)-c2cnn(C)c2C(F)(F)F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1

InChI Key: InChIKey=CEMQTUFNPNQGJE-FOGDFJRCSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM227331
PNG
(US9328106, 282)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2cnn(C)c2C(F)(F)F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C19H22F4N8O2S/c1-30-14(12-4-3-10(24)9(20)7-33-12)11(6-27-30)28-17(32)13-16(25)34-18(29-13)8-5-26-31(2)15(8)19(21,22)23/h5-6,9-10,12H,3-4,7,24-25H2,1-2H3,(H,28,32)/t9-,10-,12+/m1/s1
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PC cid
PC sid
UniChem
US Patent
0.0580 -14.0n/an/an/an/an/a7.225



Genentech Inc

US Patent


Assay Description
LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...


US Patent US9328106 (2016)


BindingDB Entry DOI: 10.7270/Q29W0DBT
More data for this
Ligand-Target Pair