BindingDB logo
myBDB logout

BDBM227721 3-bromo-n-(1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine::US9556181, 15::US9556181, 6::US9556181, 9

SMILES: Brc1n[nH]c2ncnc(Nc3ccc4[nH]ncc4c3)c12

InChI Key: InChIKey=SKMNMXMMGNJTPP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 227721   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227721
PNG
(3-bromo-n-(1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyri...)
Show SMILES Brc1n[nH]c2ncnc(Nc3ccc4[nH]ncc4c3)c12
Show InChI InChI=1S/C12H8BrN7/c13-10-9-11(14-5-15-12(9)20-19-10)17-7-1-2-8-6(3-7)4-16-18-8/h1-5H,(H,16,18)(H2,14,15,17,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/a7.5n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)


BindingDB Entry DOI: 10.7270/Q2C53NTH
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227721
PNG
(3-bromo-n-(1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyri...)
Show SMILES Brc1n[nH]c2ncnc(Nc3ccc4[nH]ncc4c3)c12
Show InChI InChI=1S/C12H8BrN7/c13-10-9-11(14-5-15-12(9)20-19-10)17-7-1-2-8-6(3-7)4-16-18-8/h1-5H,(H,16,18)(H2,14,15,17,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/a7.5n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)


BindingDB Entry DOI: 10.7270/Q2C53NTH
More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227721
PNG
(3-bromo-n-(1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyri...)
Show SMILES Brc1n[nH]c2ncnc(Nc3ccc4[nH]ncc4c3)c12
Show InChI InChI=1S/C12H8BrN7/c13-10-9-11(14-5-15-12(9)20-19-10)17-7-1-2-8-6(3-7)4-16-18-8/h1-5H,(H,16,18)(H2,14,15,17,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/a7.5n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)


BindingDB Entry DOI: 10.7270/Q2C53NTH
More data for this
Ligand-Target Pair