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BDBM227762 8-[(Ethylamino)methyl]-4-[(5-hydroxy-2-methylphenyl)amino]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one::US10047096, 25

SMILES: CCNCc1ccc2Nc3nccc(Nc4cc(O)ccc4C)c3C(=O)Nc2c1

InChI Key: InChIKey=BWHGTIFBFVAAKP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227762   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM227762
PNG
(8-[(Ethylamino)methyl]-4-[(5-hydroxy-2-methylpheny...)
Show SMILES CCNCc1ccc2Nc3nccc(Nc4cc(O)ccc4C)c3C(=O)Nc2c1
Show InChI InChI=1S/C22H23N5O2/c1-3-23-12-14-5-7-16-19(10-14)27-22(29)20-17(8-9-24-21(20)26-16)25-18-11-15(28)6-4-13(18)2/h4-11,23,28H,3,12H2,1-2H3,(H,27,29)(H2,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.25n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFRβ (amino acids R561-L1106), expr...


US Patent US10047096 (2018)


BindingDB Entry DOI: 10.7270/Q23R0VW4
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM227762
PNG
(8-[(Ethylamino)methyl]-4-[(5-hydroxy-2-methylpheny...)
Show SMILES CCNCc1ccc2Nc3nccc(Nc4cc(O)ccc4C)c3C(=O)Nc2c1
Show InChI InChI=1S/C22H23N5O2/c1-3-23-12-14-5-7-16-19(10-14)27-22(29)20-17(8-9-24-21(20)26-16)25-18-11-15(28)6-4-13(18)2/h4-11,23,28H,3,12H2,1-2H3,(H,27,29)(H2,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.4n/an/an/an/a7.0n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...


US Patent US10047096 (2018)


BindingDB Entry DOI: 10.7270/Q23R0VW4
More data for this
Ligand-Target Pair