BDBM22881 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine::Amthamine::CHEMBL554964
SMILES Cc1nc(N)sc1CCN
InChI Key InChIKey=LHVRFUVVRXGZPV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 22881
Affinity DataKi: 5.01E+3nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2More data for this Ligand-Target Pair
Affinity DataKi: 5.01E+3nM ΔG°: -7.52kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 6.31E+3nMAssay Description:Displacement of [125I]iodoaminopotentidine from human histamine H2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKd: 1.15E+4nMAssay Description:Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 1.58E+4nMAssay Description:Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 191nMAssay Description:Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assayMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 191nMAssay Description:Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assayMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataEC50: 617nMAssay Description:Agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rateMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKd: 5.01E+3nMAssay Description:Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligandMore data for this Ligand-Target Pair