BindingDB logo
myBDB logout

BDBM228814 PZA::Pyrazinamide::Tisamid::pyrazinecarboxamide

SMILES: NC(=O)c1cnccn1

InChI Key: InChIKey=IPEHBUMCGVEMRF-UHFFFAOYSA-N

Data: 5 IC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 228814   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sirtuin-6 (SIRT6)


(Homo sapiens (Human))
BDBM228814
PNG
(PZA | Pyrazinamide | Tisamid | pyrazinecarboxamide)
Show SMILES NC(=O)c1cnccn1
Show InChI InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 4.17E+5n/an/an/an/an/an/a



University at Albany



Assay Description
Inhibitory constants (Ki) and IC50 values were determined under saturating substrate conditions by using a fluorimetric assay (components were purcha...


Chembiochem 18: 931-940 (2017)


Article DOI: 10.1002/cbic.201600655
BindingDB Entry DOI: 10.7270/Q2CJ8CC2
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM228814
PNG
(PZA | Pyrazinamide | Tisamid | pyrazinecarboxamide)
Show SMILES NC(=O)c1cnccn1
Show InChI InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Canalicular multispecific organic anion transporter 1


(Homo sapiens (Human))
BDBM228814
PNG
(PZA | Pyrazinamide | Tisamid | pyrazinecarboxamide)
Show SMILES NC(=O)c1cnccn1
Show InChI InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Canalicular multispecific organic anion transporter 2


(Homo sapiens (Human))
BDBM228814
PNG
(PZA | Pyrazinamide | Tisamid | pyrazinecarboxamide)
Show SMILES NC(=O)c1cnccn1
Show InChI InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair
Multidrug resistance-associated protein 4


(Homo sapiens (Human))
BDBM228814
PNG
(PZA | Pyrazinamide | Tisamid | pyrazinecarboxamide)
Show SMILES NC(=O)c1cnccn1
Show InChI InChI=1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...


Toxicol Sci 136: 216-41 (2013)


Article DOI: 10.1093/toxsci/kft176
BindingDB Entry DOI: 10.7270/Q2JM2D2D
More data for this
Ligand-Target Pair