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BDBM229947 US9334269, 274

SMILES: CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2c(F)cccc2F)c1

InChI Key: InChIKey=YMSUUFPKSFHWOA-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 229947   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM229947
PNG
(US9334269, 274)
Show SMILES CNC(=O)c1cccc(Nc2ncnc(n2)N2CC(C2)Oc2c(F)cccc2F)c1
Show InChI InChI=1S/C20H18F2N6O2/c1-23-18(29)12-4-2-5-13(8-12)26-19-24-11-25-20(27-19)28-9-14(10-28)30-17-15(21)6-3-7-16(17)22/h2-8,11,14H,9-10H2,1H3,(H,23,29)(H,24,25,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.21E+4n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
Compounds were tested on human Nav1.7 (hNav1.7) expressed stably in 293 cells, which have no endogenous sodium channels. Two forms of whole-cell patc...


US Patent US9334269 (2016)


BindingDB Entry DOI: 10.7270/Q2M32TNF
More data for this
Ligand-Target Pair