BDBM229983 2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1h-pyrrole-3-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 1

SMILES Cc1cc(C(=O)NCc2ccc3c(N)nccc3c2)c(C)n1Cc1csc(n1)-c1ccccc1

InChI Key InChIKey=NDPHLXVHICHOPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 229983   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM229983(2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1h-py...)
Affinity DataIC50: >1.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM229983(2,5-dimethyl-1-(2-phenyl-thiazol-4-ylmethyl)-1h-py...)
Affinity DataIC50:  54.7nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent