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BDBM230192 US9340500, I-036

SMILES: CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CCOC1

InChI Key: InChIKey=LFKVLSOCMMMVTE-UHFFFAOYNA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 230192   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM230192
PNG
(US9340500, I-036)
Show SMILES CN(CCCn1c(C)c(cc1-c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F)CC1CCOC1
Show InChI InChI=1/C28H32F3N3O2/c1-20-25(27(35)32-24-11-6-10-23(16-24)28(29,30)31)17-26(22-8-4-3-5-9-22)34(20)14-7-13-33(2)18-21-12-15-36-19-21/h3-6,8-11,16-17,21H,7,12-15,18-19H2,1-2H3,(H,32,35)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.00E+3 -8.51n/an/an/an/an/an/a37



Shionogi & Co., Ltd

US Patent


Assay Description
Test Example 3: (1) The TRPV4 inhibitory activity was measured using CHO-K1 cells stably expressing human TRPV4 (hTRPV4/CHO cells). (2) Frozen cells ...


US Patent US9340500 (2016)


BindingDB Entry DOI: 10.7270/Q2319TR3
More data for this
Ligand-Target Pair