BDBM231468 US9346798, 215
SMILES Fc1cc2N(CCOc2cc1S(=O)(=O)Nc1nccs1)c1ccc(cc1C#N)C(F)(F)F
InChI Key InChIKey=YYWBVRDWEWYDOV-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 231468
Affinity DataIC50: 203nMAssay Description:HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...More data for this Ligand-Target Pair
Affinity DataIC50: 9.86nMAssay Description:HEK 293 cells stably transfected with either Nav 1.7 or with Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro auto...More data for this Ligand-Target Pair
Affinity DataIC50: 183nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Displacement of (P)-1-(30-chloro-2-fluoro-5,50-dimethoxy-[1,10biphenyl]-4-yl)-N-(isoxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide[50-methoxy-C...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of rat NaV1.7 by cell based whole cell voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of NaV1.8 in rat DRG neurons assessed as reduction in tetrodotoxin-sensitive sodium channel currents at holding potential of -140 mV by ma...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of NaV1.8 in C57BL/6 mouse DRG neurons assessed as reduction in tetrodotoxin-sensitive sodium channel currents at holding potential of -14...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of human NaV1.5 expressed in HEK295 cells at holding potential of -125 mV with test potentials to -10 mV by whole cell voltage clamp metho...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse NaV1.7 by whole cell voltage clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human NaV1.7 expressed in HEK293 cells at holding potential of -125 mV with test potentials to -10 mV by whole cell voltage clamp metho...More data for this Ligand-Target Pair