BDBM23398 (2Z)-1-{5-[(4-fluorophenyl)methyl]furan-2-yl}-3-hydroxy-3-(1H-1,2,4-triazol-3-yl)prop-2-en-1-one::CHEMBL368084::S-1360

SMILES Fc1ccc(Cc2ccc(o2)C(=O)CC(=O)c2nnc[nH]2)cc1

InChI Key InChIKey=RQQWCYPROZEXIC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 23398   

TargetIntegrase(Human immunodeficiency virus type 1)
Katholieke Universiteit Leuven

Curated by ChEMBL
LigandPNGBDBM23398(CHEMBL368084 | (2Z)-1-{5-[(4-fluorophenyl)methyl]f...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against human immunodeficiency virus type 1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Katholieke Universiteit Leuven

Curated by ChEMBL
LigandPNGBDBM23398(CHEMBL368084 | (2Z)-1-{5-[(4-fluorophenyl)methyl]f...)
Affinity DataIC50: 20nMAssay Description:Strand transfer inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM23398(CHEMBL368084 | (2Z)-1-{5-[(4-fluorophenyl)methyl]f...)
Affinity DataIC50: 20nMAssay Description:Concentration required to inhibit catalytic activity of human immuno deficiency virus type 1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23398(CHEMBL368084 | (2Z)-1-{5-[(4-fluorophenyl)methyl]f...)
Affinity DataIC50: 46nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2008
Entry Details Article
PubMed