BDBM23513 N-hydroxy-4-({[4-(pent-3-yn-2-yloxy)benzene]sulfonyl}methyl)-1-(propane-2-sulfonyl)piperidine-4-carboxamide::beta-sulfonyl hydroxamate analogue, 27

SMILES CC#CC(C)Oc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)S(=O)(=O)C(C)C)C(=O)NO

InChI Key InChIKey=UFOCAFMHHPCHKN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23513   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM23513(N-hydroxy-4-({[4-(pent-3-yn-2-yloxy)benzene]sulfon...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM23513(N-hydroxy-4-({[4-(pent-3-yn-2-yloxy)benzene]sulfon...)
Affinity DataIC50:  2.91E+3nMT: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM23513(N-hydroxy-4-({[4-(pent-3-yn-2-yloxy)benzene]sulfon...)
Affinity DataIC50:  4.18E+3nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed