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BDBM237128 US9388199, 38

SMILES: CC(F)(F)CCNC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12

InChI Key: InChIKey=RIFUBRRDCBYLAQ-DWJHFUFGNA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 237128   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor D


(Homo sapiens (Human))
BDBM237128
PNG
(US9388199, 38)
Show SMILES CC(F)(F)CCNC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1/C20H23F2N5O3/c1-20(21,22)6-7-24-19(30)15-9-11-8-14(11)27(15)16(28)10-26-13-5-3-2-4-12(13)17(25-26)18(23)29/h2-5,11,14-15H,6-10H2,1H3,(H2,23,29)(H,24,30)/t11-,14-,15+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.05E+3n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...


US Patent US9388199 (2016)


BindingDB Entry DOI: 10.7270/Q25X27TW
More data for this
Ligand-Target Pair