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BDBM237229 1-(2, 4-Difluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-phenylthiourea (10b)

SMILES: COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2F)ccc1O

InChI Key: InChIKey=RCBNLLJFNHOFTB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 237229   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237229
PNG
(1-(2, 4-Difluorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2F)ccc1O
Show InChI InChI=1S/C21H18F2N2O2S/c1-27-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(28)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.92E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)


Article DOI: 10.3109/14756366.2011.608665
BindingDB Entry DOI: 10.7270/Q2N015FS
More data for this
Ligand-Target Pair