BDBM23723 4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl-1H-pyrazole::N-Benzoylpyrazole deriv., 31::cid_714833

SMILES COc1ccc(cc1)C(=O)n1nc(C)c(Br)c1C

InChI Key InChIKey=NLSJGZBQMCEPIO-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23723   

TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  2.45E+4nM ΔG°:  -6.29kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Thrombin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  2.84E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPlasma kallikrein(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Kallikrein activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Cathepsin D assays were monitored with a Fluoroskan Ascent FL microtiter plate reader at excitation and emission wavelengths of 340 and 390 nm, respe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  7.60E+3nMAssay Description:Chymotrypsin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23723(4-bromo-1-[(4-methoxyphenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Urokinase activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed