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BDBM237300 4-Methyl-N-o-tolyl-benzenesulfonamide (5)

SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1C

InChI Key: InChIKey=SIPGNSRRMHEOSA-UHFFFAOYSA-N

Data: 2 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 237300   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM237300
PNG
(4-Methyl-N-o-tolyl-benzenesulfonamide (5))
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1C
Show InChI InChI=1S/C14H15NO2S/c1-11-7-9-13(10-8-11)18(16,17)15-14-6-4-3-5-12(14)2/h3-10,15H,1-2H3
PDB
MMDB

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UniChem
Article
PubMed
386 -8.74n/an/an/an/an/a7.525



Ataturk University



Assay Description
An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...


J Enzyme Inhib Med Chem 28: 294-8 (2013)


Article DOI: 10.3109/14756366.2012.658788
BindingDB Entry DOI: 10.7270/Q2TH8KKX
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM237300
PNG
(4-Methyl-N-o-tolyl-benzenesulfonamide (5))
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1C
Show InChI InChI=1S/C14H15NO2S/c1-11-7-9-13(10-8-11)18(16,17)15-14-6-4-3-5-12(14)2/h3-10,15H,1-2H3
PDB
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Article
PubMed
615 -8.47n/an/an/an/an/a7.525



Ataturk University



Assay Description
An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...


J Enzyme Inhib Med Chem 28: 294-8 (2013)


Article DOI: 10.3109/14756366.2012.658788
BindingDB Entry DOI: 10.7270/Q2TH8KKX
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM237300
PNG
(4-Methyl-N-o-tolyl-benzenesulfonamide (5))
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1C
Show InChI InChI=1S/C14H15NO2S/c1-11-7-9-13(10-8-11)18(16,17)15-14-6-4-3-5-12(14)2/h3-10,15H,1-2H3
PDB
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KEGG

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Article
PubMed
n/an/a 407n/an/an/an/an/an/a



Ataturk University



Assay Description
Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...


J Enzyme Inhib Med Chem 27: 818-24 (2012)


Article DOI: 10.3109/14756366.2011.617745
BindingDB Entry DOI: 10.7270/Q2G73CKP
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM237300
PNG
(4-Methyl-N-o-tolyl-benzenesulfonamide (5))
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1C
Show InChI InChI=1S/C14H15NO2S/c1-11-7-9-13(10-8-11)18(16,17)15-14-6-4-3-5-12(14)2/h3-10,15H,1-2H3
PDB
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NCI pathway
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KEGG

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Article
PubMed
n/an/a 1.48E+5n/an/an/an/an/an/a



Ataturk University



Assay Description
Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...


J Enzyme Inhib Med Chem 27: 818-24 (2012)


Article DOI: 10.3109/14756366.2011.617745
BindingDB Entry DOI: 10.7270/Q2G73CKP
More data for this
Ligand-Target Pair
Carbonic anhydrase 6 (CA-VI)


(Homo sapiens (Human))
BDBM237300
PNG
(4-Methyl-N-o-tolyl-benzenesulfonamide (5))
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1C
Show InChI InChI=1S/C14H15NO2S/c1-11-7-9-13(10-8-11)18(16,17)15-14-6-4-3-5-12(14)2/h3-10,15H,1-2H3
PDB

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antibodypedia
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PC sid
UniChem
Article
PubMed
n/an/a 2.96E+4n/an/an/an/an/an/a



Ataturk University



Assay Description
Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...


J Enzyme Inhib Med Chem 27: 818-24 (2012)


Article DOI: 10.3109/14756366.2011.617745
BindingDB Entry DOI: 10.7270/Q2G73CKP
More data for this
Ligand-Target Pair