BDBM238375 3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1gg)

SMILES: CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12

InChI Key: InChIKey=SGOZDYFIDIJHFF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 238375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Saccharomyces cerevisiae (Baker's yeast))	BDBM238375 (3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair
Farnesyltransferase (FTase) (Trypanosoma brucei brucei)	BDBM238375 (3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)	KEGG UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM238375 (3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair