BindingDB logo
myBDB logout

BDBM238445 US9394297, 72

SMILES: Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC1CC(O)C1

InChI Key: InChIKey=RRSYIVJLGUPYPY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 238445   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238445
PNG
(US9394297, 72)
Show SMILES Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC1CC(O)C1
Show InChI InChI=1S/C20H21N5O2/c1-10-19(23-11-7-12(26)8-11)25-18-13(3-2-4-16(18)22-10)17-9-14-15(24-17)5-6-21-20(14)27/h2-4,9,11-12,24,26H,5-8H2,1H3,(H,21,27)(H,23,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238445
PNG
(US9394297, 72)
Show SMILES Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC1CC(O)C1
Show InChI InChI=1S/C20H21N5O2/c1-10-19(23-11-7-12(26)8-11)25-18-13(3-2-4-16(18)22-10)17-9-14-15(24-17)5-6-21-20(14)27/h2-4,9,11-12,24,26H,5-8H2,1H3,(H,21,27)(H,23,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.10n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair