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BDBM238783 US9394297, 470

SMILES: Cc1nc2cccc(-c3cc4C(=O)NC(CO)c4n3C)c2nc1NC(C)(C)C

InChI Key: InChIKey=GFNSSGCOEONQCH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 238783   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM238783
PNG
(US9394297, 470)
Show SMILES Cc1nc2cccc(-c3cc4C(=O)NC(CO)c4n3C)c2nc1NC(C)(C)C
Show InChI InChI=1S/C21H25N5O2/c1-11-19(25-21(2,3)4)24-17-12(7-6-8-14(17)22-11)16-9-13-18(26(16)5)15(10-27)23-20(13)28/h6-9,15,27H,10H2,1-5H3,(H,23,28)(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.80n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM238783
PNG
(US9394297, 470)
Show SMILES Cc1nc2cccc(-c3cc4C(=O)NC(CO)c4n3C)c2nc1NC(C)(C)C
Show InChI InChI=1S/C21H25N5O2/c1-11-19(25-21(2,3)4)24-17-12(7-6-8-14(17)22-11)16-9-13-18(26(16)5)15(10-27)23-20(13)28/h6-9,15,27H,10H2,1-5H3,(H,23,28)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/a7.022



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9394297 (2016)


BindingDB Entry DOI: 10.7270/Q2G44P78
More data for this
Ligand-Target Pair