BDBM23954 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoic acid::CHEMBL494::ILOPROST::Ventavis::[3H]-Iloprost
SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O
InChI Key InChIKey=HIFJCPQKFCZDDL-ACWOEMLNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 23954
Affinity DataKi: 1nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]-Iloprost radioligand from cloned human IP receptorMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP1 subtype(Mus musculus (Mouse))
Kyoto University
Curated by PDSP Ki Database
Kyoto University
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Kyoto University
Curated by PDSP Ki Database
Kyoto University
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP2 subtype(Mus musculus (Mouse))
Kyoto University
Curated by PDSP Ki Database
Kyoto University
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP4 subtype(Mus musculus (Mouse))
Kyoto University
Curated by PDSP Ki Database
Kyoto University
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataKi: 3.70E+3nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 2A1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataEC50: 2.09E+3nMAssay Description:Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of c...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
Affinity DataEC50: 2.06E+3nMAssay Description:Agonist activity at human DP1 expressed in human 1321N1 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins additio...More data for this Ligand-Target Pair
Affinity DataEC50: 0.690nMAssay Description:Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by H...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
Affinity DataEC50: 147nMAssay Description:Agonist activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation b...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Merck Frosst Centre For Therapeutic Research
Curated by PDSP Ki Database
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human EP1 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of c...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Prostaglandin I2 receptor binding by displacement of [3H]-iloprost from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair