BDBM239755 Roche-Dataset for PDE10A, Compound 359::US9394311, 38

SMILES Cc1cc(c(n2c1nc(n2)CCc3nc(nn3C)N4CCCC4)C)Cl

InChI Key InChIKey=NCSCZUVPQAFJGQ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 239755   

LigandPNGBDBM239755(US9394311, 38 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 0.280nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM239755(US9394311, 38 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 0.280nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

LigandPNGBDBM239755(US9394311, 38 | Roche-Dataset for PDE10A, Compound...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full-length recombinant human PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed