BDBM243277 9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazolyl)-7-((3-fluoro- 1-azetidinyl)carbonyl)-9H- carbazole-1-carboxamide::US10053454, Example 21::US10196387, Example 21

SMILES Cc1noc(C)c1-c1cc(C(N)=O)c2n(c3cc(ccc3c2c1)C(=O)N1CC(F)C1)S(=O)(=O)C1CC1

InChI Key InChIKey=FPPMHSHLUYXZBJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 243277   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243277(9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazo...)
Affinity DataIC50: <50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243277(9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazo...)
Affinity DataIC50: <50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM243277(9-(cyclopropylsulfonyl)-3-(3,5- dimethyl-4-isoxazo...)
Affinity DataIC50: <50nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent