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BDBM243349 4-{5-[3-Methy1-5-(4- trifluoromethyl-pyrimidin- 2-ylamino)-phenyl]- oxazol-2-yl}-4,7-diaza- spiro[2.5]octan-8-one::US10053455, 005

SMILES: Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(o1)N1CCNC(=O)C11CC1

InChI Key: InChIKey=YYSWMXHUKQVKGA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243349   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM243349
PNG
(4-{5-[3-Methy1-5-(4- trifluoromethyl-pyrimidin- 2-...)
Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(o1)N1CCNC(=O)C11CC1
Show InChI InChI=1S/C21H19F3N6O2/c1-12-8-13(10-14(9-12)28-18-26-5-2-16(29-18)21(22,23)24)15-11-27-19(32-15)30-7-6-25-17(31)20(30)3-4-20/h2,5,8-11H,3-4,6-7H2,1H3,(H,25,31)(H,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/a7.825



AB SCIENCE

US Patent


Assay Description
SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...


US Patent US10053455 (2018)


BindingDB Entry DOI: 10.7270/Q27946PV
More data for this
Ligand-Target Pair