BDBM243375 6-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N-ethyl-7-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxamide::US10053458, 7

SMILES CCNC(=O)N1CCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc2C1

InChI Key InChIKey=BKHPDBWZFWUODJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 243375   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM243375(6-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...)
Affinity DataIC50: <10nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM243375(6-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...)
Affinity DataIC50:  50nMAssay Description:Inhibition of crizotinib-resistant ALK L1196M mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM243375(6-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

US Patent
LigandPNGBDBM243375(6-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)py...)
Affinity DataIC50: <10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent