BDBM244562 US10226449, cpd 171::US9428502, 171

SMILES Cc1nc([nH]c1-c1cc(C(=O)N2CC(C2)c2ccc(cc2)C#N)c(C)cc1C)C1CCOC1

InChI Key

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244562   

TargetFatty acid synthase(Homo sapiens (Human))
3-V Biosciences

US Patent
LigandPNGBDBM244562(US10226449, cpd 171 | US9428502, 171)
Affinity DataIC50:  21nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
3-V Biosciences

US Patent
LigandPNGBDBM244562(US10226449, cpd 171 | US9428502, 171)
Affinity DataEC50:  5nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
3-V Biosciences

US Patent
LigandPNGBDBM244562(US10226449, cpd 171 | US9428502, 171)
Affinity DataIC50:  21nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent