BDBM24484 4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin-3-yl]methoxy}-7-methoxyquinoline::Triazolopyridazine, 10n::US9066954, 214

SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccco3)ccnc2c1

InChI Key InChIKey=GQWWLPVCCXCECH-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24484   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24484(4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin...)
Affinity DataKi:  17.6nM ΔG°:  -10.6kcal/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM24484(4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin...)
Affinity DataIC50:  29nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed