BDBM24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33

SMILES: Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1

InChI Key: InChIKey=OVPNQJVDAFNBDN-UHFFFAOYSA-N

Data: 4 IC50  442 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 447 hits for monomerid = 24654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47	n/a	n/a	n/a	n/a	7.2	22
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 5 activator 1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (2019-nCoV)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.52E+4	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase BRSK1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Calcium/calmodulin-dependent protein kinase kinase 2 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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eIF-2-alpha kinase GCN2 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 3 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase MRCK gamma (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 11A (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-6 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Calcium/calmodulin-dependent protein kinase type II subunit beta (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Protein kinase C eta type (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase D2 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-4 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 6 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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MAP/microtubule affinity-regulating kinase 3 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Myosin-IIIb (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM24654 (pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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