BDBM246868 US10053465, 7::US10065963, Compound 7::US10125150, Example 7::US10336759, # 7::US10479803, Example 7::US10519163, Example 7::US10675284, Example 7::US10875847, Compound INCB39110::US11084822, Example 7::US11130767, # 7::US11136326, Example 7::US11285140, Example 364::US11304949, Compound 1::US11324749, Comp. No. 1::US11406640, Comp. No. 1::US11596632, Comp. No. 1::US11918581, Compound 1::US11957661, Compound 4::US11992490, Compound 1::US20240058343, Compound 1::US20240307353, Compound 4::US9732097, Example 7::US9999619, Example 364::{1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl] piperidin-4- yl}-3-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-3- yl}acetonitrile

SMILES: Fc1c(ccnc1C(F)(F)F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key: InChIKey=KTBSXLIQKWEBRB-UHFFFAOYSA-N

Data: 66 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 80 hits for monomerid = 246868   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	488	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	385	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	324	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	795	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	7.8	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246868 ({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair