BDBM24688 10-hydroxy-DDACTHF, 10S-7::2-({4-[(1S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-hydroxybutyl]phenyl}formamido)pentanedioic acid
SMILES Nc1nc(N)c(CCC[C@H](O)c2ccc(cc2)C(=O)NC(CCC(O)=O)C(O)=O)c(=O)[nH]1
InChI Key InChIKey=OGTRQJJZWHQCBC-KZUDCZAMSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 24688
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: 1.40E+3nM ΔG°: -8.01kcal/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute
The Scripps Research Institute
Affinity DataKi: >1.00E+5nM ΔG°: >-5.47kcal/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair