BDBM24694 4-aminopyrazolylpyrimidine analogue, 5::5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)on1

InChI Key InChIKey=MJQVDJSEAMOVCO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24694   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM24694(4-aminopyrazolylpyrimidine analogue, 5 | 5-bromo-4...)
Affinity DataIC50:  270nMpH: 7.4 T: 2°CAssay Description:TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM24694(4-aminopyrazolylpyrimidine analogue, 5 | 5-bromo-4...)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:TrkB kinase activity was measured against its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using homog...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed