BDBM248897 US9434725, 128

SMILES CCn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CC[C@@H](O)C1

InChI Key InChIKey=SYPBNOXLIVCNCJ-MRXNPFEDSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 248897   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248897(US9434725, 128)
Affinity DataKi:  4.39nM ΔG°:  -11.4kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248897(US9434725, 128)
Affinity DataKi:  7.22nM ΔG°:  -11.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248897(US9434725, 128)
Affinity DataKi:  56.7nM ΔG°:  -9.88kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent