BDBM248909 US9434725, 140

SMILES CCn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCC(N)CC1

InChI Key InChIKey=NVFQLDLNJAOHJA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 248909   

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248909(US9434725, 140)
Affinity DataKi:  0.454nM ΔG°:  -12.7kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248909(US9434725, 140)
Affinity DataKi:  1.04nM ΔG°:  -12.2kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248909(US9434725, 140)
Affinity DataKi:  13.4nM ΔG°:  -10.7kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent