BDBM249007 US9434725, 238

SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cnc(C2CC2)c(n1)N1CCC[C@H](N)C1

InChI Key InChIKey=VPGFPXLEFFWPKW-KRWDZBQOSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 249007   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249007(US9434725, 238)
Affinity DataKi:  0.0260nM ΔG°:  -14.4kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249007(US9434725, 238)
Affinity DataKi:  0.0320nM ΔG°:  -14.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249007(US9434725, 238)
Affinity DataKi:  0.257nM ΔG°:  -13.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent