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BDBM249056 US9434725, 287

SMILES: O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1

InChI Key: InChIKey=GNAXCGUONRASLS-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 249056   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM249056
PNG
(US9434725, 287)
Show SMILES O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C19H18N8O/c28-19-12-21-11-15(24-19)14-8-16-13(9-22-14)10-23-27(16)18-3-1-2-17(25-18)26-6-4-20-5-7-26/h1-3,8-12,20H,4-7H2,(H,24,28)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.370 -12.9n/an/an/an/an/a7.225



F. Hoffmann-La Roche Inc

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9434725 (2016)


BindingDB Entry DOI: 10.7270/Q2CF9P1N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM249056
PNG
(US9434725, 287)
Show SMILES O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C19H18N8O/c28-19-12-21-11-15(24-19)14-8-16-13(9-22-14)10-23-27(16)18-3-1-2-17(25-18)26-6-4-20-5-7-26/h1-3,8-12,20H,4-7H2,(H,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
0.698 -12.5n/an/an/an/an/a7.225



F. Hoffmann-La Roche Inc

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9434725 (2016)


BindingDB Entry DOI: 10.7270/Q2CF9P1N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM249056
PNG
(US9434725, 287)
Show SMILES O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C19H18N8O/c28-19-12-21-11-15(24-19)14-8-16-13(9-22-14)10-23-27(16)18-3-1-2-17(25-18)26-6-4-20-5-7-26/h1-3,8-12,20H,4-7H2,(H,24,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
17.5 -10.6n/an/an/an/an/a7.225



F. Hoffmann-La Roche Inc

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9434725 (2016)


BindingDB Entry DOI: 10.7270/Q2CF9P1N
More data for this
Ligand-Target Pair