BDBM249056 US9434725, 287

SMILES: O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1

InChI Key: InChIKey=GNAXCGUONRASLS-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 249056   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM249056 (US9434725, 287) Show SMILES O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C19H18N8O/c28-19-12-21-11-15(24-19)14-8-16-13(9-22-14)10-23-27(16)18-3-1-2-17(25-18)26-6-4-20-5-7-26/h1-3,8-12,20H,4-7H2,(H,24,28)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.370	-12.9	n/a	n/a	n/a	n/a	n/a	7.2	25
F. Hoffmann-La Roche Inc US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM249056 (US9434725, 287) Show SMILES O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C19H18N8O/c28-19-12-21-11-15(24-19)14-8-16-13(9-22-14)10-23-27(16)18-3-1-2-17(25-18)26-6-4-20-5-7-26/h1-3,8-12,20H,4-7H2,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	0.698	-12.5	n/a	n/a	n/a	n/a	n/a	7.2	25
F. Hoffmann-La Roche Inc US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM249056 (US9434725, 287) Show SMILES O=c1cncc([nH]1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C19H18N8O/c28-19-12-21-11-15(24-19)14-8-16-13(9-22-14)10-23-27(16)18-3-1-2-17(25-18)26-6-4-20-5-7-26/h1-3,8-12,20H,4-7H2,(H,24,28)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	17.5	-10.6	n/a	n/a	n/a	n/a	n/a	7.2	25
F. Hoffmann-La Roche Inc US Patent					Assay Description PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...				US Patent US9434725 (2016) BindingDB Entry DOI: 10.7270/Q2CF9P1N
					More data for this Ligand-Target Pair