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BDBM24934 2-amino-isoxazolopyridine, 13::3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}pyrido[4,3-d][1,2]oxazol-3-yl)phenyl]propan-1-ol

SMILES: C[C@H](Nc1cc2c(noc2cn1)-c1cc(Cl)cc(CCCO)c1)c1ccccc1

InChI Key: InChIKey=MMGKIHLBFPJYJL-HNNXBMFYSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24934   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM24934
PNG
(2-amino-isoxazolopyridine, 13 | 3-[3-chloro-5-(5-{...)
Show SMILES C[C@H](Nc1cc2c(noc2cn1)-c1cc(Cl)cc(CCCO)c1)c1ccccc1
Show InChI InChI=1S/C23H22ClN3O2/c1-15(17-7-3-2-4-8-17)26-22-13-20-21(14-25-22)29-27-23(20)18-10-16(6-5-9-28)11-19(24)12-18/h2-4,7-8,10-15,28H,5-6,9H2,1H3,(H,25,26)/t15-/m0/s1
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UniProtKB/SwissProt

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MMDB
PC cid
PC sid
PDB
UniChem

Similars

DrugBank
Article
PubMed
n/an/a 99n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair