BDBM249490 US10072016, Compound 88::US10407433, Compound 88::US10913746, Compound 88::US11649240, Compound 88::US9434727, 88::US9777010, Compound 88

SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CCN(CC4CC4)Cc23)c(c1F)C(F)(F)F

InChI Key InChIKey=LLZJRMIXDPBPBN-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 249490   

TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  14.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  39nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  18.0nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  39.0nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  14.7nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  18nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  13.4nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  39nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  14.7nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  13.4nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  14.7nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  13.4nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  14.7nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  13.4nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  14.7nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  18nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  13.4nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249490(US10072016, Compound 88 | US10407433, Compound 88 ...)
Affinity DataIC50:  13.4nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent