BDBM25008 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK screening, 27::oxadiazole-containing compound, 3b

SMILES CCn1c(nc2c(ncc(OCC3CCNCC3)c12)C#CC(C)(C)O)-c1nonc1N

InChI Key InChIKey=NTPAYIOIMIUCMN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25008   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25008(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Technical University Of Dortmund

LigandPNGBDBM25008(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)
Affinity DataIC50:  718nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25008(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)
Affinity DataIC50:  40nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25008(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(pip...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed