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BDBM250481 US9464044, 114

SMILES: NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(c(Cl)c4)C(F)(F)F)c1)C(C3)C2

InChI Key: InChIKey=YPDYULKWEMLFPN-CJEYPXOASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250481   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM250481
PNG
(US9464044, 114)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(c(Cl)c4)C(F)(F)F)c1)C(C3)C2
Show InChI InChI=1S/C25H25ClF3N3O4S/c26-20-9-18(4-5-19(20)25(27,28)29)37(35,36)32-17-3-1-2-14(8-17)22(33)31-21-15-6-13-7-16(21)12-24(10-13,11-15)23(30)34/h1-5,8-9,13,15-16,21,32H,6-7,10-12H2,(H2,30,34)(H,31,33)/t13?,15?,16?,21-,24?
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 30.7n/an/an/an/a6.025



Ahn-Gook Pharmaceutical Co. Ltd

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


US Patent US9464044 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JH0
More data for this
Ligand-Target Pair