BDBM25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115

SMILES: Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1

InChI Key: InChIKey=UJIAQDJKSXQLIT-UHFFFAOYSA-N

Data: 12 IC50  442 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 454 hits for monomerid = 25084   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	83	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	235	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	83	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	235	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	235	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 6 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-6 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cyclin-dependent kinase 11A (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Calcium/calmodulin-dependent protein kinase type II subunit beta (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase kinase 2 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D2 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TNNI3K (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Myosin-IIIb (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein kinase C eta type (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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SRSF protein kinase 2 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase MRCK gamma (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Macrophage-stimulating protein receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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eIF-2-alpha kinase GCN2 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Hepatocyte growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-5 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase BRSK1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Insulin receptor (Human)	BDBM25084 (JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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