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BDBM250912 US9452986, 216

SMILES: FC(F)(F)c1ccc(Oc2ccc3nc(ccc3c2)C(=O)NC2CNC2)nc1

InChI Key: InChIKey=WUJPWPAWXFHLIH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250912   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM250912
PNG
(US9452986, 216)
Show SMILES FC(F)(F)c1ccc(Oc2ccc3nc(ccc3c2)C(=O)NC2CNC2)nc1
Show InChI InChI=1S/C19H15F3N4O2/c20-19(21,22)12-2-6-17(24-8-12)28-14-3-5-15-11(7-14)1-4-16(26-15)18(27)25-13-9-23-10-13/h1-8,13,23H,9-10H2,(H,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.67E+3n/an/an/an/an/a37



AbbVie Inc

US Patent


Assay Description
Two days prior to the experiment, frozen HEK293 cells stably expressing recombinant human Nav1.7 were quickly thawed and plated at 25,000 cells/well ...


US Patent US9452986 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RQS
More data for this
Ligand-Target Pair