BDBM25115 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(pyrrolidin-1-yl)butyl]carbamoyl}amino)-1,2-thiazole-4-carboxamide::CHEMBL253969::CP 547632::CP547632, 24::US9446026, 1

SMILES: c1c(cc(c(c1F)COc2c(c(sn2)NC(=O)NCCCCN3CCCC3)C(=O)N)F)Br

InChI Key: InChIKey=HXHAJRMTJXHJJZ-UHFFFAOYSA-N

Data: 4 KI  28 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 25115   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11.1	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	122	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	419	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54.2	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 4 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Discoidin domain-containing receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
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Discoidin domain-containing receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	422	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 3 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33.9	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.08	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase B (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	207	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor A (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.27	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.79	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
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Putative glycogen synthase kinase 3 alpha (Corn smut fungus)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK1 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	7.5	22
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Serine/threonine-protein kinase PLK3 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK2 (Human)	BDBM25115 (3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	7.5	22
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