BDBM25116 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL306380::PP1::US10688093, Compound PP1 (Pfizer)::US10807986, Comparative compound 1::US11046696, Compound 1 of Comparative Examples::US11701353, PP1 (Pfizer)::cid_1400

SMILES: Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key: InChIKey=ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Data: 8 KI  36 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 25116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase LCK (Mouse)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>30	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 14 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase CSK (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform delta (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 2 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase mTOR (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	657	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mast/stem cell growth factor receptor Kit (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Yes (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ZAP-70 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase JAK2 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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60S ribosomal protein L19-A (Baker's yeast)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	825	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Angiopoietin-1 receptor (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform delta (Rat)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase PLK2 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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Serine/threonine-protein kinase PLK3 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM25116 (cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.00E+4	>-6.34	n/a	n/a	n/a	n/a	n/a	7.5	22
TBA									Citation and Details
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