BindingDB PrimarySearch

BDBM25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US20250129067, Compound Axitinib::US9205078, Axitinib ::US9617222, Compound A

SMILES: CNC(=O)c1ccccc1Sc2ccc3c(c2)[nH]nc3/C=C/c4ccccn4

InChI Key: InChIKey=RITAVMQDGBJQJZ-UHFFFAOYSA-N

Data: 8 KI 35 IC50 446 Kd

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 489 hits for monomerid = 25117
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase TBK1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.78	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.551	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	25
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.418	n/a	n/a	n/a	n/a	7.5	25
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Platelet-derived growth factor receptor alpha (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	977	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
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Protein delta homolog 1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK4 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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eIF-2-alpha kinase GCN2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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MAP/microtubule affinity-regulating kinase 3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
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Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25117 (AG-013736 \| N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a
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