BDBM25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258::US20250129067, Compound Dovitinib

SMILES: CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O

InChI Key: InChIKey=PIQCTGMSNWUMAF-UHFFFAOYSA-N

Data: 17 KI  35 IC50  885 Kd  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 940 hits for monomerid = 25118   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	630	n/a	n/a	n/a	7.4	25
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ALK tyrosine kinase receptor (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase B (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
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Bone morphogenetic protein receptor type-2 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 7 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.80E+3	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK4 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.50E+3	n/a	n/a	n/a	7.4	23
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	60	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	69	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.640	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.10	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.60	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.80	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	580	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 3 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 4 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a
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Muscle, skeletal receptor tyrosine-protein kinase (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-4 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-5 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
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BDNF/NT-3 growth factors receptor (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a
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NT-3 growth factor receptor (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
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Fibroblast growth factor receptor 4 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM25118 (4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a
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